The biggest problem in oral drug delivery is low and erratic bioavailability, which mainly results from one or more factors. This, in turn, may lead to irreproducible clinical response or a therapeutic failure in some cases due to sub therapeutic plasma drug levels. From an economic point of view, low oral bioavailability results in the wasting of a large portion of an oral dose and adds to the cost of drug therapy, especially when the drug is an expensive one. Several pharmaceutical companies over the last few years much research efforts have been made in this area to adverse various biological and technological issues. Now a day the liquisolid system comes in a picture as an innovative approach for improving the low bioavailability of poorly soluble drugs by increasing their solubility. The term \"liquisolid systems\" refers to powdered forms of liquid medications formulated by converting liquid lipophilic drugs, or drug suspensions or solutions of water-insoluble solid drugs in suitable non-volatile solvent systems, into \"dry\" (i.e., dry-looking), nonadherent, free-flowing and readily compressible powder admixtures by blending with selected carrier and coating materials.
Loading....